Spider silk-based particles: new drug delivery vesicles for targeted cancer therapy
نویسندگان
چکیده
Bioengineered spider silk is a biomaterial that combines superb mechanical properties, biocompatibility and biodegradability with a good accessibility and simple purification procedure. Thus, spider silk has extensively been explored as material for numerous biomedical applications. Silk protein can self-assemble in the high phosphate ion concentration and under mixing conditions into spheres of nanoand micrometrical sizes. Moreover, the bioengineered silk protein may be further modified to gain new functions. Particularly, nanoparticles able to target cancer cells could be designed by addition of tumor homing peptides within the silk structural sequence.
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